2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile

Base Information

• Chemical Name: 2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile
• CAS No.: 490022-84-9
• Molecular Formula: C₂₅H₁₆F₂N₄O₂S
• Molecular Weight: 474.49
• Mol file: 490022-84-9.mol

Synonyms:2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile

Chemical Property of 2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile

There total 1 articles about 2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

orthoformic acid triethyl ester (122-51-0) + 5-amino-7-(4-fluorophenyl)-2-[(4-fluorophenyl)methylene]-2,3-dihydro-3-oxo-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile (339157-09-4) → 2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile (490022-84-9)

Guidance literature:

With acetic anhydride; for 10h; Heating;

DOI:10.1080/10426500210240

Reference yield: 70.0%

2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile (490022-84-9) → 7-amino-2-(4-fluorophenyl)methylidene-9-(4-fluorophenyl)-8-imino-3-oxo-2,3,7,8-tetrahydro-9H-thiazolo[2',3':1,6]pyrido[2,3-d]pyrimidin-10-carbonitrile

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 2h;

DOI:10.1080/10426500210240

Reference yield: 65.0%

isopropylamine (75-31-0) + 2-(4-fluorophenyl)methylidene-7-(4-fluorophenyl)-2,3-dihydro-5-ethoxyethyleneamino-7H-3-oxo-thiazolo[3,2-a]pyrimidin-6,8-dicarbonitrile (490022-84-9) → 2-(4-fluorophenyl)methylidene-9-(4-fluorophenyl)-7-isopropyl-8-imino-3-oxo-2,3,7,8-tetrahydro-9H-thiazolo[2',3':1,6]pyrido[2,3-d]pyrimidin-10-carbonitrile

Guidance literature:

In ethanol; for 1h; Heating;

DOI:10.1080/10426500210240

upstream raw materials:

orthoformic acid triethyl ester

5-amino-7-(4-fluorophenyl)-2-[(4-fluorophenyl)methylene]-2,3-dihydro-3-oxo-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile