9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

Base Information

Chemical Name:9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine
CAS No.:190773-84-3
Molecular Formula:C₂₄H₂₄FN₅O₇S₂
Molecular Weight:577.614
Hs Code.:

Synonyms:9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

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Technology Process of 9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

There total 9 articles about 9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 127246-62-2
2',5'-di-O-(p-toluenesulfonyl)adenosine

: 190773-84-3
9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

Guidance literature:: With cesium fluoride; 4,4'-diaminostilbene-2,2'-disulfonic acid; In 1,4-dioxane; for 48h; Ambient temperature;
DOI:10.1016/S0040-4020(97)00313-X

Reference yield:

: 10457-15-5
O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine

: 190773-84-3
9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

Guidance literature:: Multi-step reaction with 3 steps

1: aq. NH₃ / methanol / 0.5 h

2: 1.) Bu₂SnO, 2.) (Bu₃Sn)2O, 3.) pyridine / 1.) MeOH, reflux, 30 min, 2.) C₆H₆, reflux, 2 h, 3.) 5 deg C, 48 h

3: 94 percent / CsF, DAST / dioxane / 48 h / Ambient temperature

With pyridine; ammonium hydroxide; di(n-butyl)tin oxide; cesium fluoride; 4,4'-diaminostilbene-2,2'-disulfonic acid; bis(tri-n-butyltin)oxide; In 1,4-dioxane; methanol;
DOI:10.1016/S0040-4020(97)00313-X

Reference yield:

: 60091-08-9
8-bromo-2',3',5'-(triOTMS)adenosine

: 190773-84-3
9-[3-deoxy-3-fluoro-2,5-di-O-(p-toluenesulfonyl)-β-D-xylopyranosyl]adenine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium naphthalenide / tetrahydrofuran / -60 °C

2: aq. NH₃ / methanol / 0.5 h

3: 1.) Bu₂SnO, 2.) (Bu₃Sn)2O, 3.) pyridine / 1.) MeOH, reflux, 30 min, 2.) C₆H₆, reflux, 2 h, 3.) 5 deg C, 48 h

4: 94 percent / CsF, DAST / dioxane / 48 h / Ambient temperature

With pyridine; ammonium hydroxide; sodium naphthalenide; di(n-butyl)tin oxide; cesium fluoride; 4,4'-diaminostilbene-2,2'-disulfonic acid; bis(tri-n-butyltin)oxide; In tetrahydrofuran; 1,4-dioxane; methanol;
DOI:10.1016/S0040-4020(97)00313-X