(S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

Base Information

Chemical Name:(S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate
CAS No.:101250-46-8
Molecular Formula:C₁₆H₂₄N₂O₄
Molecular Weight:308.378
Hs Code.:

Synonyms:(S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

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Chemical Property of (S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

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Technology Process of (S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

There total 6 articles about (S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7533-40-6,14438-11-0
(S)-2-amino-4-methylpentan-1-ol

: 101250-46-8
(S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 64 percent / NaOAc / acetone; H₂O / 2 h / Ambient temperature

2: 24 percent / NaH / tetrahydrofuran / 14 h / Ambient temperature

3: aq. HCl / 4 h / Heating

4: aq. NaOH / 1 h

5: 1.) methyl chloroformate, Et₃N, 2.) NH₃ / 1.) CH₂Cl₂, from -5 deg C to 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 1 h

With hydrogenchloride; sodium hydroxide; ammonia; sodium acetate; sodium hydride; triethylamine; methyl chloroformate; In tetrahydrofuran; water; acetone;
DOI:10.1021/jm00156a012

Reference yield:

: 101250-43-5
(S)-2-chloro-N-<1-(hydroxymethyl)-3-methylbutyl>acetamide

: 101250-46-8
(S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 24 percent / NaH / tetrahydrofuran / 14 h / Ambient temperature

2: aq. HCl / 4 h / Heating

3: aq. NaOH / 1 h

4: 1.) methyl chloroformate, Et₃N, 2.) NH₃ / 1.) CH₂Cl₂, from -5 deg C to 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 1 h

With hydrogenchloride; sodium hydroxide; ammonia; sodium hydride; triethylamine; methyl chloroformate; In tetrahydrofuran;
DOI:10.1021/jm00156a012

Reference yield:

: 101250-45-7
(S)-<<4-methyl-2-<<(phenylmethoxy)carbonyl>amino>pentyl>oxy>acetic acid

: 101250-46-8
(S)-phenylmethyl <1-<(2-amino-2-oxoethoxy)methyl>-3-methylbutyl>carbamate

Guidance literature:: With ammonia; triethylamine; methyl chloroformate; Yield given. Multistep reaction; 1.) CH₂Cl₂, from -5 deg C to 0 deg C, 30 min, 2.) CH₂Cl₂, RT, 1 h;
DOI:10.1021/jm00156a012