C₂₈H₂₉NO₇

Base Information

• Chemical Name: C₂₈H₂₉NO₇
• CAS No.: 910138-85-1
• Molecular Formula: C₂₈H₂₉NO₇
• Molecular Weight: 491.541
• Mol file: 910138-85-1.mol

Synonyms:C₂₈H₂₉NO₇

Chemical Property of C₂₈H₂₉NO₇

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₈H₂₉NO₇

There total 22 articles about C₂₈H₂₉NO₇ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

C20H23NO5 (910138-83-9) + benzyl chloroformate (501-53-1,94274-21-2) → C28H29NO7 (910138-85-1)

Guidance literature:

With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.1021/ja063304f

Reference yield:

C17H17NO5 (910138-79-3) → C28H29NO7 (910138-85-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 75 percent / Cs₂CO₃ / acetonitrile / 20 h / 25 °C

2.1: AgOTf / CH₂Cl₂ / 1 h / 25 °C

2.2: 77 percent / TBAT / CH₂Cl₂ / 20 h / -45 - 25 °C

3.1: 74 percent / samarium diiodide; HMPA / 2-methyl-propan-2-ol / 3 h / -78 - -45 °C

4.1: 99 percent / Schwartz's reagent / tetrahydrofuran / 16 h / Heating

5.1: 86 percent / KHMDS / tetrahydrofuran / 1 h / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; Schwartz's reagent; silver trifluoromethanesulfonate; potassium hexamethylsilazane; caesium carbonate; In tetrahydrofuran; dichloromethane; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ja063304f

Reference yield:

6-chloro-2,2-dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one (1040271-76-8) → C28H29NO7 (910138-85-1)

Guidance literature:

Multi-step reaction with 7 steps

1.1: 85 percent / triethylamine / tetrahydrofuran / 3 h / 25 °C

2.1: 76 percent / Cs₂CO₃ / dioxane / 18 h / Heating

3.1: 75 percent / Cs₂CO₃ / acetonitrile / 20 h / 25 °C

4.1: AgOTf / CH₂Cl₂ / 1 h / 25 °C

4.2: 77 percent / TBAT / CH₂Cl₂ / 20 h / -45 - 25 °C

5.1: 74 percent / samarium diiodide; HMPA / 2-methyl-propan-2-ol / 3 h / -78 - -45 °C

6.1: 99 percent / Schwartz's reagent / tetrahydrofuran / 16 h / Heating

7.1: 86 percent / KHMDS / tetrahydrofuran / 1 h / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; Schwartz's reagent; silver trifluoromethanesulfonate; potassium hexamethylsilazane; caesium carbonate; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile; tert-butyl alcohol;

DOI:10.1021/ja063304f

upstream raw materials:

C₂₀H₂₃NO₅

benzyl chloroformate

6-chloro-2,2-dimethyl-3a,6a-dihydro-cyclopenta[1,3]dioxol-4-one

(-)-6-chloro-2,2-dimethyl-4,6a-dihydro-3aH-cyclopenta[1,3]dioxol-4-ol

Downstream raw materials:

C₂₅H₂₅NO₇

C₂₅H₂₃NO₆

C₃₀H₃₁NO₉

(-)-Cephalotaxinone