2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

Base Information

Chemical Name:2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester
CAS No.:132298-13-6
Molecular Formula:C₁₃H₁₅NO₅
Molecular Weight:265.266
Hs Code.:

Synonyms:2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

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Chemical Property of 2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

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Technology Process of 2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

There total 4 articles about 2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 132298-12-5
2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid benzyl ester methyl ester

: 132298-13-6
2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2.5h; under 760 Torr; Ambient temperature;
DOI:10.1021/jo00005a060

Reference yield:

: 132298-11-4
(R)-1-(4-Amino-phenyl)-2-chloro-propan-1-one

: 132298-13-6
2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 12 h, r.t. 2) DMF, 25 h, r.t.

2: 0.8 g / H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 760 Torr / Ambient temperature

With hydrogen; sodium hydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jo00005a060

Reference yield:

: 132298-10-3
N-[4-((R)-2-Chloro-propionyl)-phenyl]-acetamide

: 132298-13-6
2-[(R)-2-(4-Amino-phenyl)-1-methyl-2-oxo-ethyl]-malonic acid monomethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 6 N H₂SO₄ / methanol / 2 h / Heating

2: 1) NaH / 1) DMF, 12 h, r.t. 2) DMF, 25 h, r.t.

3: 0.8 g / H₂ / 10percent Pd/C / ethyl acetate / 2.5 h / 760 Torr / Ambient temperature

With sulfuric acid; hydrogen; sodium hydride; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1021/jo00005a060