4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

Base Information

Chemical Name:4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride
CAS No.:1040860-85-2
Molecular Formula:C₁₃H₁₂ClF₃O₂
Molecular Weight:292.685
Hs Code.:

Synonyms:4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

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Chemical Property of 4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

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Technology Process of 4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

There total 3 articles about 4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1035261-84-7
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid

: 1040860-85-2
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

Guidance literature:: With thionyl chloride; at 75 ℃; for 1.5h;

Reference yield:

: 2338-76-3
3-trifluoromethylphenylacetonitrile

: 1040860-85-2
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.17 h / 0 °C

1.2: 6 h / 0 - 20 °C

2.1: sulfuric acid; water / 21 h / 110 °C

3.1: thionyl chloride / 1.5 h / 75 °C

With thionyl chloride; sulfuric acid; potassium tert-butylate; water; In N,N-dimethyl-formamide;

Reference yield:

: 1035261-83-6
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carbonitrile

: 1040860-85-2
4-(3-(trifluoromethyl)phenyl)-tetrahydro-2H-pyran-4-carboxylic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid; water / 21 h / 110 °C

2: thionyl chloride / 1.5 h / 75 °C

With thionyl chloride; sulfuric acid; water;