2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

Base Information

Chemical Name:2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite
CAS No.:108783-02-4
Molecular Formula:C34H45 N2 O7 P S
Molecular Weight:656.78
Hs Code.:
European Community (EC) Number:853-148-0
Nikkaji Number:J1.007.657I
Mol file:108783-02-4.mol

Synonyms:2-((2-(bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite;3-[2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethylsulfonyl]ethoxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile;(2-CYANOETHOXY)-2-(2''-O-1,1''-DIMETHOXYTRITYLOXYETHYLSULFONYL)- ETHOXY-N,N-DIISOPROPYLAMINOPHOSPHINE);2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(n,n-diisopropyl)-phosphoramidite;SCHEMBL2205161;MFCD00036168;AC-32411;CS-0311370;N,N-Diisopropylamide phosphorous acid 2-cyanoethyl 2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl ester

Suppliers and Price of 2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 24 raw suppliers

Chemical Property of 2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

Chemical Property:

PSA：129.29000
LogP:7.80048
XLogP3:5.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:19
Exact Mass:656.26850995
Heavy Atom Count:45
Complexity:944

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)N(C(C)C)P(OCCC#N)OCCS(=O)(=O)CCOC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)C3=CC=C(C=C3)OC

Technology Process of 2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite

There total 2 articles about 2-((2-(Bis(4-methoxyphenyl)(phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 108783-01-3
2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethanol

: 108783-02-4
2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 25 ℃;
DOI:10.1016/S0040-4039(00)85043-1

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 108783-02-4
2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

Guidance literature:: Multi-step reaction with 2 steps

1: 10.0 g / pyridine / 18 h / in the dark

2: N,N-diisopropylethylamine (DIPEA) / CH₂Cl₂ / 0 - 25 °C

With N-ethyl-N,N-diisopropylamine; In pyridine; dichloromethane;
DOI:10.1016/S0040-4039(00)85043-1

Reference yield:

: 108783-02-4
2-[2-(4,4'-dimethoxytrityloxy)ethylsulfonyl]ethyl-(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite

: 87358-01-8
thymidine 5'-phosphonate

: 50-89-5,28854-96-8,3545-96-8,50-88-4
thymidine

Guidance literature:: With ammonium hydroxide; 1H-tetrazole; Multistep reaction; 1.) dry acetonitrile; 2.) 60 deg C;
DOI:10.1016/S0040-4039(00)85043-1