N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine

Base Information

• Chemical Name: N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine
• CAS No.: 121158-56-3
• Molecular Formula: C₁₃H₁₈N₆
• Molecular Weight: 262.31
• Mol file: 121158-56-3.mol

Synonyms:N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine

Chemical Property of N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine

There total 7 articles about N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,6-diethylaniline (579-66-8) → N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine (121158-56-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 69.9 percent / POCl₃ / 3 h / Heating

2: 91.1 percent / H₂O / 3 h / Heating

3: 1.) NaNO₂, AcOH, 2.) 35percent HNO₃ / 1.) H₂O, 5 deg C, 1.5 h, 2.) a) 5 deg C, 0.5 h, b) reflux, 1 h

4: Fe, HCl / ethanol; H₂O / 0.5 h / Heating

5: 56.3 percent / Br₂ / acetic acid; trifluoroacetic acid / 1.) ice-bath temperature, 1.5 h, 2.) ice-bath temperature -> room temperature

6: T₂ / 10percent Pd/C / 2 h

7: 1.) NaNO₂, N HCl, 2.) NaN₃ / 1.) H₂O, 0 deg C, 10 min, 2.) 0 deg C, 1 h

With hydrogenchloride; sodium azide; tritium; water; bromine; nitric acid; iron; acetic acid; sodium nitrite; trichlorophosphate; palladium on activated charcoal; In ethanol; water; acetic acid; trifluoroacetic acid;

DOI:10.1021/jm00128a022

Reference yield:

1-acetyl-N-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine (86861-31-6) → N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine (121158-56-3)

Guidance literature:

Multi-step reaction with 6 steps

1: 91.1 percent / H₂O / 3 h / Heating

2: 1.) NaNO₂, AcOH, 2.) 35percent HNO₃ / 1.) H₂O, 5 deg C, 1.5 h, 2.) a) 5 deg C, 0.5 h, b) reflux, 1 h

3: Fe, HCl / ethanol; H₂O / 0.5 h / Heating

4: 56.3 percent / Br₂ / acetic acid; trifluoroacetic acid / 1.) ice-bath temperature, 1.5 h, 2.) ice-bath temperature -> room temperature

5: T₂ / 10percent Pd/C / 2 h

6: 1.) NaNO₂, N HCl, 2.) NaN₃ / 1.) H₂O, 0 deg C, 10 min, 2.) 0 deg C, 1 h

With hydrogenchloride; sodium azide; tritium; water; bromine; nitric acid; iron; acetic acid; sodium nitrite; palladium on activated charcoal; In ethanol; water; acetic acid; trifluoroacetic acid;

DOI:10.1021/jm00128a022

Reference yield:

N-(2,6-diethyl-4-nitrophenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine (86861-32-7) → N-(4-azido-2,6-diethyl<3,5-(3)H2>phenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine (121158-56-3)

Guidance literature:

Multi-step reaction with 4 steps

1: Fe, HCl / ethanol; H₂O / 0.5 h / Heating

2: 56.3 percent / Br₂ / acetic acid; trifluoroacetic acid / 1.) ice-bath temperature, 1.5 h, 2.) ice-bath temperature -> room temperature

3: T₂ / 10percent Pd/C / 2 h

4: 1.) NaNO₂, N HCl, 2.) NaN₃ / 1.) H₂O, 0 deg C, 10 min, 2.) 0 deg C, 1 h

With hydrogenchloride; sodium azide; tritium; bromine; iron; sodium nitrite; palladium on activated charcoal; In ethanol; water; acetic acid; trifluoroacetic acid;

DOI:10.1021/jm00128a022

upstream raw materials:

C₁₃H₁₈⁽³⁾H₂N₄

2,6-diethylaniline

2,6-dibromo-4-[(4,5-dihydro-1H-imidazol-2(3H)-ylidene)amino]-3,5-diethylbenzenamine

1-acetyl-N-(2,6-diethylphenyl)-4,5-dihydro-1H-imidazol-2(3H)-imine