N-benzyloxycarbonyl-phenylalanine benzyl ester

Base Information

• Chemical Name: N-benzyloxycarbonyl-phenylalanine benzyl ester
• CAS No.: 103063-37-2
• Molecular Formula: C₂₄H₂₃NO₄
• Molecular Weight: 389.451
• Mol file: 103063-37-2.mol

Synonyms:N-benzyloxycarbonyl-phenylalanine benzyl ester

Chemical Property of N-benzyloxycarbonyl-phenylalanine benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-benzyloxycarbonyl-phenylalanine benzyl ester

There total 9 articles about N-benzyloxycarbonyl-phenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + DL-phenylalanine benzyl ester (962-39-0,25282-53-5,47004-38-6) → N-benzyloxycarbonyl-phenylalanine benzyl ester (103063-37-2)

Guidance literature:

With 4-methyl-morpholine; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 17h;

DOI:10.1002/anie.201406857

Reference yield:

Z-DL-Phe-OH (3588-57-6) + benzyl alcohol (100-51-6,185532-71-2) → N-benzyloxycarbonyl-phenylalanine benzyl ester (103063-37-2)

Guidance literature:

With toluene-4-sulfonic acid; benzene;

DOI:10.1021/jo50012a002

Reference yield:

C24H15Cl4NO4 → N-benzyloxycarbonyl-phenylalanine benzyl ester (103063-37-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethylenediamine / tetrahydrofuran / 20 h / 20 °C / Inert atmosphere

2: 4-methyl-morpholine / methanol; tetrahydrofuran / 17 h / 0 - 20 °C

With 4-methyl-morpholine; ethylenediamine; In tetrahydrofuran; methanol;

DOI:10.1002/anie.201406857

upstream raw materials:

Z-DL-Phe-OH

benzyl alcohol

benzyl chloroformate

DL-phenylalanine benzyl ester

Refernces