N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Base Information

Chemical Name:N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine
CAS No.:1447969-94-9
Molecular Formula:C₂₂H₂₆N₄O₁₀
Molecular Weight:506.469
Hs Code.:

N<sup>4</sup>-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Synonyms:N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Suppliers and Price of N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Chemical Property:

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Technology Process of N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

There total 3 articles about N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1447969-93-8
N⁴-acetyl-3’,5’-O-di-tert-silyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

: 1447969-94-9
N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Guidance literature:: With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; Inert atmosphere;
DOI:10.1016/j.tetlet.2013.06.001

Reference yield:

: 1447969-90-5
N⁴-acetyl-3’, 5’-O-di-tert-silyl-2’-O-[(methylthio)methyl]cytidine

: 1447969-94-9
N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Guidance literature:: Multi-step reaction with 2 steps

1: bromine; trimethylsilylacetylene; 18-crown-6 ether / 1,2-dichloro-ethane / 1 h / Cooling with ice; Inert atmosphere

2: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / Inert atmosphere

With 18-crown-6 ether; bromine; triethylamine tris(hydrogen fluoride); trimethylsilylacetylene; In tetrahydrofuran; 1,2-dichloro-ethane;
DOI:10.1016/j.tetlet.2013.06.001

Reference yield:

: 1245818-50-1
N⁴-acetyl-3’,5’-O-di-tert-silyl cytidine

: 1447969-94-9
N⁴-acetyl-2’-O-[[2-methyl-2-(2-nitrophenyl)-1-oxopropoxy]methyl]cytidine

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; acetic anhydride / 72 h / 20 °C

2: bromine; trimethylsilylacetylene; 18-crown-6 ether / 1,2-dichloro-ethane / 1 h / Cooling with ice; Inert atmosphere

3: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / Inert atmosphere

With 18-crown-6 ether; bromine; acetic anhydride; acetic acid; triethylamine tris(hydrogen fluoride); trimethylsilylacetylene; In tetrahydrofuran; 1,2-dichloro-ethane; 1: |Pummerer Sulfoxide Rearrangement;
DOI:10.1016/j.tetlet.2013.06.001