(2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

Base Information

Chemical Name:(2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane
CAS No.:1333213-11-8
Molecular Formula:C₂₁H₂₉NO₅
Molecular Weight:375.465
Hs Code.:

Synonyms:(2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

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Chemical Property of (2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

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Technology Process of (2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

There total 5 articles about (2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1333213-10-7
(Z)-N-(3,4-dimethoxybenzylidine)-1(S)-((S)-1,4-dioxaspiro[4,5]decane-2-yl)but-3-en-1-amine oxide

: 1333213-11-8
(2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:: In toluene; for 30h; stereoselective reaction; Reflux; Inert atmosphere;
DOI:10.1021/ol2019967

Reference yield:

: 78008-36-3
(R)-2,3-cyclohexylideneglyceraldehyde

: 1333213-11-8
(2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium sulfate / tetrahydrofuran / 0.17 h / 5 °C / Inert atmosphere

1.2: 5 - 20 °C / Inert atmosphere

2.1: diethyl ether / 12.5 h / -30 °C / Inert atmosphere

3.1: sodium tungstate heptahydrate; dihydrogen peroxide / water; acetone / 12 h

4.1: toluene / 30 h / Reflux; Inert atmosphere

With sodium tungstate heptahydrate; dihydrogen peroxide; magnesium sulfate; In tetrahydrofuran; diethyl ether; water; acetone; toluene;
DOI:10.1021/ol2019967

Reference yield:

: 5763-61-1
3,4-dimethoxybenzylamine

: 1333213-11-8
(2R,4R,6S)-2-(3,4-dimethoxyphenyl)-6-((S)-1,4-dioxaspiro[4,5]decane-2-yl)-7-oxa-1-azabicyclo[2.2.1]heptane

Guidance literature:: Multi-step reaction with 4 steps

1.1: magnesium sulfate / tetrahydrofuran / 0.17 h / 5 °C / Inert atmosphere

1.2: 5 - 20 °C / Inert atmosphere

2.1: diethyl ether / 12.5 h / -30 °C / Inert atmosphere

3.1: sodium tungstate heptahydrate; dihydrogen peroxide / water; acetone / 12 h

4.1: toluene / 30 h / Reflux; Inert atmosphere

With sodium tungstate heptahydrate; dihydrogen peroxide; magnesium sulfate; In tetrahydrofuran; diethyl ether; water; acetone; toluene;
DOI:10.1021/ol2019967