3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide

Base Information

Chemical Name:3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide
CAS No.:1332299-65-6
Molecular Formula:C₂₁H₁₉F₂N₅O₂
Molecular Weight:411.411
Hs Code.:

Synonyms:3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide

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Technology Process of 3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide

There total 2 articles about 3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332302-05-2
2-chloro-5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidine

: 25900-61-2
3-amino-N-methylbenzamide

: 1332299-65-6
3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide

Guidance literature:: With trifluoroacetic acid; In isopropyl alcohol; at 84 ℃; for 72h; Sealed tube;

Reference yield:

: 63843-78-7
3-(4-fluorophenoxy)-azetidine hydrochloride

: 1332299-65-6
3-(5-fluoro-4-(3-(4-fluorophenoxy)azetidin-1-yl)pyrimidin-2-ylamino)-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 20 °C

2: trifluoroacetic acid / isopropyl alcohol / 72 h / 84 °C / Sealed tube

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In isopropyl alcohol;