2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

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Chemical Name:2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone
CAS No.:144455-08-3
Molecular Formula:C₃₃H₃₃N₇O
Molecular Weight:543.671
Hs Code.:

Synonyms:2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

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Chemical Property of 2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

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Technology Process of 2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

There total 4 articles about 2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 109-01-3
1-methyl-piperazine

: 144454-94-4
{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-acetic acid

: 144455-08-3
2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

Guidance literature:: With diphenylphosphoranyl azide; triethylamine; In N,N-dimethyl-formamide; at 4 ℃; for 15h;

Reference yield:

: 131890-73-8
1-(2-hydroxy-2-phenylethyl)-3,5-diphenyl-1H-pyrazole

: 144455-08-3
2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / dimethyl sulfoxide, acetic anhydride / 24 h / Ambient temperature

2: 79 percent / 8 h / Heating

3: 85 percent / sodium ethoxide / ethanol / 12 h / Heating

4: 78 percent / diphenylphosphorylazide, triethylamine / dimethylformamide / 15 h / 4 °C

With diphenylphosphoranyl azide; sodium ethanolate; acetic anhydride; dimethyl sulfoxide; triethylamine; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 144455-09-4
1-(2-oxo-2-phenylethyl)-3,5-diphenyl-1H-pyrazole

: 144455-08-3
2-{[5-(3,5-Diphenyl-pyrazol-1-yl)-4-phenyl-pyrimidin-2-yl]-methyl-amino}-1-(4-methyl-piperazin-1-yl)-ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 8 h / Heating

2: 85 percent / sodium ethoxide / ethanol / 12 h / Heating

3: 78 percent / diphenylphosphorylazide, triethylamine / dimethylformamide / 15 h / 4 °C

With diphenylphosphoranyl azide; sodium ethanolate; triethylamine; In ethanol; N,N-dimethyl-formamide;