7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

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Chemical Name:7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one
CAS No.:83232-24-0
Molecular Formula:C₃₃H₃₀N₂O₅S
Molecular Weight:566.678
Hs Code.:

Synonyms:7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

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Chemical Property of 7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

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Technology Process of 7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

There total 4 articles about 7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 83232-21-7
3-amino-4-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)thiophene-2-carboxamide

: 122-51-0
orthoformic acid triethyl ester

: 83232-24-0
7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

Guidance literature:: With 4 A molecular sieve; at 95 ℃; for 24h;
DOI:10.1021/jo00145a005

Reference yield:

: 83232-25-1
3-(Dimethylamino-methyleneamino)-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-thiophene-2-carboxylic acid methyl ester

: 83232-24-0
7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

Guidance literature:: With ammonia; In methanol; at 70 ℃; for 72h; Yield given;
DOI:10.1021/jo00145a005

Reference yield:

: 74458-03-0,74469-92-4,83289-75-2,83289-76-3
3-(methanesulfonyloxy)-2-(2',3'-O-isopropylidene-5'-O-trityl-D-ribofuranosyl)acrylonitrile

: 83232-24-0
7-(2',3'-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-thieno<3,2-d>pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: 2.62 g / sodium carbonate / ethanol / 18 h / Heating

2: 56 percent / molecular sieve (4 Angstroem) / 24 h / 95 °C

With 4 A molecular sieve; sodium carbonate; In ethanol;
DOI:10.1021/jo00145a005