Technology Process of C20H24N2O3
There total 4 articles about C20H24N2O3 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C15H20O4; aniline;
With
O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
acetonitrile;
for 4h;
With
hydroxylamine hydrochloride; potassium hydroxide;
In
methanol;
at 0 ℃;
for 8h;
DOI:10.1016/j.bmcl.2012.09.093
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethyl acetate / 3 h
2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h
2.2: 8 h / 0 °C
With
20% palladium hydroxide-activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine;
In
ethyl acetate; acetonitrile;
DOI:10.1016/j.bmcl.2012.09.093
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / water / 0.33 h / pH 6
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.75 h / -78 °C
2.2: 1 h / -78 - 20 °C
3.1: sodium hydride / tetrahydrofuran / 0.25 h / 0 °C / Inert atmosphere
3.2: 1.25 h / -78 - 20 °C / Inert atmosphere
4.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 0.33 h / -15 °C
4.2: 3 h / -78 °C
5.1: 20% palladium hydroxide-activated charcoal; hydrogen / ethyl acetate / 3 h
6.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / acetonitrile / 4 h
6.2: 8 h / 0 °C
With
copper(l) iodide; oxalyl dichloride; sulfuric acid; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; dibutyl ether; water; ethyl acetate; acetonitrile;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation / 3.1: |Horner-Wadsworth-Emmons Olefination / 3.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2012.09.093
