8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

Base Information

Chemical Name:8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester
CAS No.:152769-03-4
Molecular Formula:C₃₀H₃₅N₃O₇
Molecular Weight:549.624
Hs Code.:

Synonyms:8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

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Chemical Property of 8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

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Technology Process of 8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

There total 6 articles about 8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89781-52-2
8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid

: 152769-03-4
8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 71.7 percent / methanol; diethyl ether

2: 2) conc. HCl / 1) toluene, -15 deg C, 1.5 h, 2) MeOH, -70 deg C, 1 h

3: 84.2 percent / KHSO₄ / 1 h / 150 °C

4: 93.7 percent / DDQ / dioxane / 14 h / 120 °C

5: 91 percent / H₂, 4N aq. HCl / 10percent Pd/C / methanol / 18 h / 23 °C / 3800 Torr

6: 2.7 g / N,N'-dicyclohexylcarbodiimide (DCC), 1H-benzotriazol-1-ol (HOBT), N-methylmorpholine (MeMorph) / N,N-dimethyl-acetamide / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; methanol; diethyl ether; N,N-dimethyl acetamide;
DOI:10.1002/hlca.19930760414

Reference yield:

: 130532-73-9
methyl 8-cyano-2-naphthoate

: 152769-03-4
8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / H₂, 4N aq. HCl / 10percent Pd/C / methanol / 18 h / 23 °C / 3800 Torr

2: 2.7 g / N,N'-dicyclohexylcarbodiimide (DCC), 1H-benzotriazol-1-ol (HOBT), N-methylmorpholine (MeMorph) / N,N-dimethyl-acetamide / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; N,N-dimethyl acetamide;
DOI:10.1002/hlca.19930760414

Reference yield:

: 116047-26-8
methyl 8-oxo-5,6,7,8-tetrahydronaphthalene-2-carboxylate

: 152769-03-4
8-[((S)-4-Benzyloxycarbonylamino-2-tert-butoxycarbonylamino-butyrylamino)-methyl]-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 2) conc. HCl / 1) toluene, -15 deg C, 1.5 h, 2) MeOH, -70 deg C, 1 h

2: 84.2 percent / KHSO₄ / 1 h / 150 °C

3: 93.7 percent / DDQ / dioxane / 14 h / 120 °C

4: 91 percent / H₂, 4N aq. HCl / 10percent Pd/C / methanol / 18 h / 23 °C / 3800 Torr

5: 2.7 g / N,N'-dicyclohexylcarbodiimide (DCC), 1H-benzotriazol-1-ol (HOBT), N-methylmorpholine (MeMorph) / N,N-dimethyl-acetamide / 24 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; potassium hydrogensulfate; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; palladium on activated charcoal; In 1,4-dioxane; methanol; N,N-dimethyl acetamide;
DOI:10.1002/hlca.19930760414