(R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

Base Information

Chemical Name:(R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate
CAS No.:1415208-86-4
Molecular Formula:C₁₂H₁₂BrFN₂OS
Molecular Weight:331.208
Hs Code.:

Synonyms:(R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

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Chemical Property of (R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

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Technology Process of (R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

There total 2 articles about (R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₈BrFN₂O₂SSi

: 1415208-86-4
(R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

: (S,S)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 70 ℃; for 6h;
DOI:10.1021/acs.joc.5b02705

Reference yield:

: 1-(5-bromo-2-fluorophenyl)-4-((tert-butyldimethylsilyl)oxy)-2-methylenebutan-1-ol

: 1415208-86-4
(R,R)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

: (S,S)-tert-butyl 7a-(2-fluoro-5-bromophenyl)-4a,5,6,7a-tetrahydro-4H-furo[2,3-d][1,3]thiazin-2-ylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: manganese(IV) oxide / chloroform / 12 h / Reflux

2: acetic acid / 12 h / 20 °C / Inert atmosphere

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 6 h / 70 °C

With manganese(IV) oxide; tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; chloroform;
DOI:10.1021/acs.joc.5b02705