3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

Base Information

Chemical Name:3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide
CAS No.:926300-89-2
Molecular Formula:C₂₄H₃₀ClF₃N₂O₇S
Molecular Weight:583.026
Hs Code.:

Synonyms:3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

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Chemical Property of 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

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Technology Process of 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

There total 7 articles about 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxypropanoic acid

: 52960-14-2
1-pentylsulfonamide

: 926300-89-2
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 2-hydroxy-4-(2-methoxyethoxy)-benzaldehyde

: 926300-89-2
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 5 h / 20 °C

3.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

4.2: 2 h / 0 °C

5.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

5.2: 20 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.03.036

Reference yield:

: 926295-63-8
2-(benzyloxy)-4-(2-methoxyethoxy)benzaldehyde

: 926300-89-2
3-[2-([3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy)-4-(2-methoxyethoxy)phenyl]-2-methoxy-N-(pentylsulfonyl)propanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 5 h / 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 2 h / 0 °C

4.1: sodium hydroxide / tetrahydrofuran; ethanol; water / 0.5 h / 50 °C

4.2: 20 °C

5.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / acetonitrile / 0 - 20 °C

With dmap; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; acetonitrile; mineral oil;
DOI:10.1016/j.bmc.2012.03.036