Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI)

Base Information

Chemical Name:Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI)
CAS No.:108510-32-3
Molecular Formula:C₉H₁₂O₂
Molecular Weight:152.193
Hs Code.:
Mol file:108510-32-3.mol

Synonyms:Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI)

Suppliers and Price of Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI)

Chemical Property:

PSA：37.30000
LogP:1.36310

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI)

There total 18 articles about Tricyclo[3.1.1.12,4]octane-3-carboxylic acid, stereoisomer (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: (1R,5S)-7-Diazo-tricyclo[3.2.1.1^2,4]nonan-6-one

: 108510-32-3
(2R,4S)-Tricyclo[3.1.1.1^2,4]octane-3-carboxylic acid

Guidance literature:: In 1,4-dioxane; water; at 0 ℃; Irradiation;

Reference yield:

: 49700-70-1
anti-tricyclo<4.2.1.1^2,5>decane

: 108510-32-3
(2R,4S)-Tricyclo[3.1.1.1^2,4]octane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 15 steps

1: 71 percent / Br₂ / CCl₄ / 1 h / 140 °C / Irradiation

2: 33 percent / DMSO

3: 1.) NaH / 1.) THF; 2.) 14 h, room temp.

4: 60 percent / CH₃C₆H₄SO₂N₃, NEt₃ / tetrahydrofuran / 24 h / Ambient temperature

5: 51 percent / methanol / 5 h / -50 °C / Irradiation

6: 90 percent / KOH / ethanol / 12 h / 80 °C

7: DMAP, DCC / CH₂Cl₂

8: 82 percent / t-BuSH / benzene / 7 h / Heating

9: 78 percent / Br₂ / CCl₄ / 1 h / 140 °C / Irradiation

10: 77 percent / DBU / dimethylformamide / 16 h / 150 °C

11: 1.) B₂H₆; 2.) NaOH, 30 percent H₂O₂ / 1.) THF, 0 deg C, 1 h; room temp., 12 h; 2.) 40 deg C, 4 h

12: 1.) ClCOCOCl, DMSO; 2.) NEt₃ / 1.) -50 deg C; 2.) -50 deg C to room temp.

13: 1.) NaH / 1.) THF; 2.) 14 h, room temp.

14: 14 percent / CH₃C₆H₄SO₂N₃, NEt₃ / tetrahydrofuran / 24 h / Ambient temperature

15: 45 percent / dioxane; H₂O / 0 °C / Irradiation

With dmap; potassium hydroxide; sodium hydroxide; oxalyl dichloride; dihydrogen peroxide; bromine; sodium hydride; 2-methylpropan-2-thiol; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; diborane; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;

Reference yield:

: 66953-28-4
anti-tricyclo<4.2.1.1^2,5>dec-2-en-9-one

: 108510-32-3
(2R,4S)-Tricyclo[3.1.1.1^2,4]octane-3-carboxylic acid

Guidance literature:: Multi-step reaction with 16 steps

1: 1.) H₂; 2.) N₂H₄, base

2: 71 percent / Br₂ / CCl₄ / 1 h / 140 °C / Irradiation

3: 33 percent / DMSO

4: 1.) NaH / 1.) THF; 2.) 14 h, room temp.

5: 60 percent / CH₃C₆H₄SO₂N₃, NEt₃ / tetrahydrofuran / 24 h / Ambient temperature

6: 51 percent / methanol / 5 h / -50 °C / Irradiation

7: 90 percent / KOH / ethanol / 12 h / 80 °C

8: DMAP, DCC / CH₂Cl₂

9: 82 percent / t-BuSH / benzene / 7 h / Heating

10: 78 percent / Br₂ / CCl₄ / 1 h / 140 °C / Irradiation

11: 77 percent / DBU / dimethylformamide / 16 h / 150 °C

12: 1.) B₂H₆; 2.) NaOH, 30 percent H₂O₂ / 1.) THF, 0 deg C, 1 h; room temp., 12 h; 2.) 40 deg C, 4 h

13: 1.) ClCOCOCl, DMSO; 2.) NEt₃ / 1.) -50 deg C; 2.) -50 deg C to room temp.

14: 1.) NaH / 1.) THF; 2.) 14 h, room temp.

15: 14 percent / CH₃C₆H₄SO₂N₃, NEt₃ / tetrahydrofuran / 24 h / Ambient temperature

16: 45 percent / dioxane; H₂O / 0 °C / Irradiation

With dmap; potassium hydroxide; sodium hydroxide; oxalyl dichloride; hydrogen; dihydrogen peroxide; bromine; sodium hydride; 2-methylpropan-2-thiol; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; dicyclohexyl-carbodiimide; diborane; hydrazine; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; benzene;