methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate
CAS No.:1448531-81-4
Molecular Formula:C₂₀H₁₇N₃O₆
Molecular Weight:395.371
Hs Code.:

Synonyms:methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

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Technology Process of methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

There total 6 articles about methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1242427-65-1
methyl 4-(3-pyridyl)-1H-pyrrole-2-carboxylate

: 367-80-6
ethyl 4-fluoro-3-nitrobenzoate

: 1448531-81-4
methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

Guidance literature:: methyl 4-(3-pyridyl)-1H-pyrrole-2-carboxylate; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

ethyl 4-fluoro-3-nitrobenzoate; In N,N-dimethyl-formamide; for 1.5h; Reflux;
DOI:10.1016/j.ejmech.2013.04.051

Reference yield:

: 1193-62-0
methyl Pyrrole-2-carboxylate

: 1448531-81-4
methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: bromine / tetrachloromethane / -10 °C

2.1: dmap / acetonitrile / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 24 h / Inert atmosphere; Reflux

4.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 1.5 h / Reflux

With dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; potassium carbonate; caesium carbonate; trifluoroacetic acid; In tetrachloromethane; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1016/j.ejmech.2013.04.051

Reference yield:

: 156237-78-4
4-bromopyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

: 1448531-81-4
methyl 1-(4-ethoxycarbonyl-2-nitrophenyl)-4-(3-pyridyl)-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / ethanol; toluene / 24 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

3.2: 1.5 h / Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; caesium carbonate; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2013.04.051