N(alpha)-(2-naphthylsulfonylglycyl)-1-(4-aminomethylphenylalanine)piperidide

Base Information

• Chemical Name: N(alpha)-(2-naphthylsulfonylglycyl)-1-(4-aminomethylphenylalanine)piperidide
• CAS No.: 108460-11-3
• Molecular Formula: C27H32 N4 O4 S
• Molecular Weight: 508.63238
• Mol file: 108460-11-3.mol

Synonyms:Acetamide,N-[1-[[4-(aminomethyl)phenyl]methyl]-2-oxo-2-(1-piperidinyl)ethyl]-2-[(2-naphthalenylsulfonyl)amino]-,(?à)-

Chemical Property of N(alpha)-(2-naphthylsulfonylglycyl)-1-(4-aminomethylphenylalanine)piperidide

Chemical Property:

• Refractive Index: 1.638
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 133.47000
• Density: 1.289g/cm³
• LogP: 5.26700

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N(alpha)-(2-naphthylsulfonylglycyl)-1-(4-aminomethylphenylalanine)piperidide

There total 1 articles about N(alpha)-(2-naphthylsulfonylglycyl)-1-(4-aminomethylphenylalanine)piperidide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.5%

N-[(S)-1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-acetamide (92771-28-3) → N-[(S)-1-(4-Aminomethyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-acetamide (108460-11-3)

Guidance literature:

With ammonia; hydrogen; nickel; In methanol;

Reference yield:

N-[(S)-1-(4-Aminomethyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-acetamide (108460-11-3) → Nα-(2-Naphthylsulfonylglycyl)-4-guanidinomethyl-phenylalaninpiperidid*HNO3 (109273-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: TEA / tetrahydrofuran / 1) 4 h, 40 deg C, 2) 65 h, r. t., 3) 12 h, reflux

2: conc. HNO₃ / methanol; acetone

With TEA; nitric acid; In tetrahydrofuran; methanol; acetone;

Reference yield:

3,5-dimethyl-1-pyrazolylformaminidium nitrate (38184-47-3) + N-[(S)-1-(4-Aminomethyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-acetamide (108460-11-3) → Nα-(2-Naphthylsulfonylglycyl)-4-guanidinomethyl-phenylalaninpiperidid (109273-51-0)

Guidance literature:

With TEA; In tetrahydrofuran; 1) 4 h, 40 deg C, 2) 65 h, r. t., 3) 12 h, reflux;

upstream raw materials:

N-[(S)-1-(4-Cyano-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-acetamide

Downstream raw materials:

Nα-(2-Naphthylsulfonylglycyl)-4-guanidinomethyl-phenylalaninpiperidid

Nα-(2-Naphthylsulfonylglycyl)-4-guanidinomethyl-phenylalaninpiperidid*HNO3