diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

Base Information

Chemical Name:diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate
CAS No.:1092380-06-7
Molecular Formula:C₂₂H₂₃ClN₂O₆
Molecular Weight:446.887
Hs Code.:

Synonyms:diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

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Chemical Property of diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

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Technology Process of diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

There total 3 articles about diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 81714-78-5
C₁₄H₁₆ClNO₄

: 102-96-5
(2-nitroethenyl)benzene

: 1092380-06-7
diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

Guidance literature:: C₁₄H₁₆ClNO₄; (2-nitroethenyl)benzene; With 1-((1R,2R)-2-N,N-dimethylaminocyclohexyl)-3-(3,5-bis(trifluoromethyl)phenyl)urea; In toluene; at 0 ℃; for 9h;

With 2,2,2-trifluoroethanol; In toluene; at 0 ℃; for 36h; enantioselective reaction;
DOI:10.1016/j.tetlet.2008.09.113

Reference yield:

: 5153-67-3
nitrostyrene

: 6829-40-9
aminomalonic acid diethyl ester

: 104-88-1
4-chlorobenzaldehyde

: 1092380-06-7
diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

: diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

Guidance literature:: With (R)-3,3'-bis(9-anthracenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; In chloroform; at -10 ℃; Overall yield = 90 %; enantioselective reaction; Molecular sieve;
DOI:10.1016/j.tetasy.2014.04.006

Reference yield:

: 6829-40-9
aminomalonic acid diethyl ester

: 102-96-5
(2-nitroethenyl)benzene

: 104-88-1
4-chlorobenzaldehyde

: 1092380-06-7
diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

: diethyl 5-(4-chlorophenyl)-4-nitro-3-phenylpyrrolidine-2,2-dicarboxylate

Guidance literature:: aminomalonic acid diethyl ester; 4-chlorobenzaldehyde; In tert-butyl methyl ether; at 0 ℃; for 2h; Molecular sieve;

(2-nitroethenyl)benzene; With C₃₁H₂₃F₁₀N₃S; In tert-butyl methyl ether; at -20 ℃; for 72h; optical yield given as %ee; stereoselective reaction;
DOI:10.1002/chem.200801410