(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

Base Information

Chemical Name:(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid
CAS No.:791131-46-9
Molecular Formula:C₂₀H₂₈O₆
Molecular Weight:364.439
Hs Code.:

Synonyms:(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

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Chemical Property of (E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

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Technology Process of (E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

There total 5 articles about (E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 791131-45-8
(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid ethyl ester

: 791131-46-9
(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 2h; Heating;
DOI:10.1021/ol048396x

Reference yield:

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 791131-46-9
(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / NaH / tetrahydrofuran / 2 h / 0 °C

2: AD-mix-β; MsNH2 / H2O; 2-methyl-propan-2-ol / 40 h / 0 °C

3: 99 percent / pTsOH*H₂O / 24 h / 20 °C

4: 91 percent / BuLi / tetrahydrofuran / 48 h / Heating

5: 65 percent / NaOH / aq. ethanol / 2 h / Heating

With sodium hydroxide; n-butyllithium; methanesulfonamide; AD-mix-β; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; water; tert-butyl alcohol; 2: Sharpless asymmetric dihydroxylation / 4: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ol048396x

Reference yield:

: 791131-42-5
(E)-6-(4-Methoxy-benzyloxy)-3-methyl-hex-3-en-2-one

: 791131-46-9
(E)-3-{(4R,5R)-5-[2-(4-Methoxy-benzyloxy)-ethyl]-2,2,4-trimethyl-[1,3]dioxolan-4-yl}-but-2-enoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: AD-mix-β; MsNH2 / H2O; 2-methyl-propan-2-ol / 40 h / 0 °C

2: 99 percent / pTsOH*H₂O / 24 h / 20 °C

3: 91 percent / BuLi / tetrahydrofuran / 48 h / Heating

4: 65 percent / NaOH / aq. ethanol / 2 h / Heating

With sodium hydroxide; n-butyllithium; methanesulfonamide; AD-mix-β; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; water; tert-butyl alcohol; 1: Sharpless asymmetric dihydroxylation / 3: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ol048396x