1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

Base Information

Chemical Name:1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene
CAS No.:946409-81-0
Molecular Formula:C₆₀H₅₄O₆
Molecular Weight:871.085
Hs Code.:

Synonyms:1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

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Chemical Property of 1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

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Technology Process of 1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

There total 6 articles about 1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 946409-79-6
1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(trimethylsilyl)ethynyl]benzene

: 946409-80-9
5-tert-butyl-1,3-diformyl-2-iodobenzene

: 946409-81-0
1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

Guidance literature:: With tetrabutyl ammonium fluoride; triethylamine; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 3h;
DOI:10.1246/cl.2007.838

Reference yield:

: 903576-94-3
5-tert-butyl-2-ethynyl-benzaldehyde

: 946409-81-0
1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / triethylamine / Pd(PPh₃)4; CuI / 2.5 h / 60 °C

2: 45 percent / iPr₂NH / Pd(PPh₃)4; CuI / tetrahydrofuran / 25 h / 60 °C

3: 60 percent / Bu₄NF; P(o-tolyl)3; triethylamine / Pd₂(dba)3*CHCl₃; CuI / tetrahydrofuran / 3 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; diisopropylamine; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1: regioselective Sonogashira coupling / 2: Sonogashira coupling / 3: in situ Sonogashira coupling;
DOI:10.1246/cl.2007.838

Reference yield:

: 903576-88-5
5-tert-butyl-2-[(trimethylsilyl)ethynyl]benzaldehyde

: 946409-81-0
1,4-bis[(4-tert-butyl-2-formylphenyl)ethynyl]-2,3-bis[(4-tert-butyl-2,6-diformylphenyl)ethynyl]benzene

Guidance literature:: Multi-step reaction with 4 steps

1: K₂CO₃ / tetrahydrofuran; methanol / 0.17 h / 20 °C

2: 60 percent / triethylamine / Pd(PPh₃)4; CuI / 2.5 h / 60 °C

3: 45 percent / iPr₂NH / Pd(PPh₃)4; CuI / tetrahydrofuran / 25 h / 60 °C

4: 60 percent / Bu₄NF; P(o-tolyl)3; triethylamine / Pd₂(dba)3*CHCl₃; CuI / tetrahydrofuran / 3 h / 20 °C

With tetrabutyl ammonium fluoride; potassium carbonate; triethylamine; diisopropylamine; tris-(o-tolyl)phosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; 2: regioselective Sonogashira coupling / 3: Sonogashira coupling / 4: in situ Sonogashira coupling;
DOI:10.1246/cl.2007.838