Technology Process of acetic acid 2-benzoylamino-1-(4-dimethylaminopyridin-3-yl)-3,3-dimethylbutyl ester
There total 9 articles about acetic acid 2-benzoylamino-1-(4-dimethylaminopyridin-3-yl)-3,3-dimethylbutyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
dichloromethane;
at 20 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/acs.joc.8b01687
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: imidazole-1-sulfonyl azide hydrochloride; potassium carbonate; copper(II) sulfate / methanol; ethyl acetate / 0 °C / Inert atmosphere
2.1: Dess-Martin periodane / dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere
3.1: tert.-butyl lithium / pentane; tetrahydrofuran / 0.5 h / -78 - -75 °C / Inert atmosphere
3.2: 0.5 h / -78 - -75 °C / Inert atmosphere
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere
5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.25 h / 20 °C / Inert atmosphere
5.2: Inert atmosphere
6.1: 20 °C / Inert atmosphere
With
imidazole-1-sulfonyl azide hydrochloride; lithium aluminium tetrahydride; tert.-butyl lithium; potassium carbonate; Dess-Martin periodane; copper(II) sulfate; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate; pentane;
DOI:10.1021/acs.joc.6b02955
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Dess-Martin periodane / dichloromethane / 2.17 h / 0 - 20 °C / Inert atmosphere
2.1: tert.-butyl lithium / pentane; tetrahydrofuran / 0.5 h / -78 - -75 °C / Inert atmosphere
2.2: 0.5 h / -78 - -75 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / dichloromethane / 0.25 h / 20 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: 20 °C / Inert atmosphere
With
lithium aluminium tetrahydride; tert.-butyl lithium; Dess-Martin periodane; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/acs.joc.6b02955
