4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

Base Information

Chemical Name:4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine
CAS No.:180992-33-0
Molecular Formula:C₁₅H₁₃ClN₂O₃S
Molecular Weight:336.799
Hs Code.:

Synonyms:4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

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Chemical Property of 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

Chemical Property:

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Technology Process of 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

There total 5 articles about 4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7073-36-1
2-chloro-4-nitrobenzoyl chloride

: 180340-57-2
5,6,7,8-tetra-hydro-4H-thieno[3,2-b]azepine

: 180992-33-0
4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

Guidance literature:: With triethylamine; In dichloromethane;
DOI:10.1016/S0960-894X(00)00084-6

Reference yield:

: 13414-95-4
4-keto-4,5,6,7-tetrahydrothianaphthene

: 180992-33-0
4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / NH₂OH*HCl; aq. NaOAc / ethanol

2: 92 percent / pyridine

3: 60 percent / aq. KOAc / ethanol

4: 91 percent / BH₃*S(CH₃)2 / tetrahydrofuran

5: Et₃N / CH₂Cl₂

With pyridine; dimethylsulfide borane complex; hydroxylamine hydrochloride; potassium acetate; sodium acetate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1: Condensation / 2: Tosylation / 3: Rearrangement / 4: Reduction / 5: Acylation;
DOI:10.1016/S0960-894X(00)00084-6

Reference yield:

: 19995-19-8,79222-03-0,79222-05-2
4,5,6,7-tetrahydro-4-oxobenzo[b]thiophene oxime

: 180992-33-0
4-(2-Chloro-4-nitrobenzoyl)-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / pyridine

2: 60 percent / aq. KOAc / ethanol

3: 91 percent / BH₃*S(CH₃)2 / tetrahydrofuran

4: Et₃N / CH₂Cl₂

With pyridine; dimethylsulfide borane complex; potassium acetate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; 1: Tosylation / 2: Rearrangement / 3: Reduction / 4: Acylation;
DOI:10.1016/S0960-894X(00)00084-6