N^α-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine

Base Information

• Chemical Name: N^α-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine
• CAS No.: 479644-49-0
• Molecular Formula: C₁₉H₃₃N₇O₄
• Molecular Weight: 423.516

Synonyms:N^α-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine

Chemical Property of N^α-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of N^α-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine

There total 5 articles about N^α-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

→ Nα-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine (479644-49-0)

Guidance literature:

Reference yield:

C19H31N7O4 → Nα-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine (479644-49-0)

Guidance literature:

With sodium tris(acetoxy)borohydride; In methanol;

DOI:10.1021/jm0202932

Reference yield:

2-nitro-benzeneacetonitrile (610-66-2) → Nα-(tert-butoxycarbonyl)-(4S)-{[4-amino-5-(2-aminophenyl)ethylamino]pentyl}-N'-nitroguanidine (479644-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: BH₃ / tetrahydrofuran / 4 h / 25 °C

1.2: aq. HCl / tetrahydrofuran / 0 °C

2.1: SnCl₂*2H₂O / ethanol / 0.5 h / 70 °C

3.1: 3A molecular sieves / methanol / 1 h / 20 °C

4.1: 415 mg / sodium triacetoxyborohydride / methanol

With 3 A molecular sieve; borane; sodium tris(acetoxy)borohydride; tin(ll) chloride; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm0202932

upstream raw materials:

2-nitro-benzeneacetonitrile

2-aminophenylacetonitrile

β-(o-aminophenyl)ethylamine

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