5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-benzyl-2'-deoxyinosine

Base Information

• Chemical Name: 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-benzyl-2'-deoxyinosine
• CAS No.: 171045-33-3
• Molecular Formula: C₃₈H₃₅FN₄O₆
• Molecular Weight: 662.718
• Mol file: 171045-33-3.mol

Synonyms:5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-benzyl-2'-deoxyinosine

Chemical Property of 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-benzyl-2'-deoxyinosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-benzyl-2'-deoxyinosine

There total 2 articles about 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O⁶-benzyl-2'-deoxyinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate + O6-benzyl-2-fluoro-2'-deoxyinosine (144640-76-6) → 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O6-benzyl-2'-deoxyinosine (171045-33-3)

Guidance literature:

With 2,6-dimethylpyridine; lithium carbonate; In tetrahydrofuran; Ambient temperature;

DOI:10.1080/07328319608002032

Reference yield: 70.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + O6-benzyl-2-fluoro-2'-deoxyinosine (144640-76-6) → 5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O6-benzyl-2'-deoxyinosine (171045-33-3)

Guidance literature:

With triethylamine; In pyridine; at 20 ℃; for 12h;

DOI:10.1021/jo982473i

Reference yield: 98.0%

5'-O-(4,4'-dimethoxytrityl)-2-fluoro-O6-benzyl-2'-deoxyinosine (171045-33-3) → 2-fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine (133947-31-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; for 0.5h; Ambient temperature;

DOI:10.1080/07328319608002032

upstream raw materials:

O⁶-benzyl-2-fluoro-2'-deoxyinosine

4,4'-dimethoxytrityl chloride

Downstream raw materials:

2-fluoro-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyinosine