N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

Base Information

Chemical Name:N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide
CAS No.:1198222-55-7
Molecular Formula:C₁₈H₂₅N₃O₆S
Molecular Weight:411.479
Hs Code.:

Synonyms:N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

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Chemical Property of N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

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Technology Process of N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

There total 7 articles about N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 10130-74-2
m-Methoxybenzenesulfonyl chloride

: 1-{[(4-amino-4-methylpentyl)oxy]methyl}-1,2,3,4-tetrahydropyrimidine-2,4-dione

: 1198222-55-7
N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jm201628y

Reference yield:

: 1198225-61-4
benzyl 5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-ylcarbamate

: 1198222-55-7
N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jm201628y

Reference yield:

: 1198225-60-3
benzyl (5-(Methoxymethoxy)-2-methylpentan-2-yl)carbamate

: 1198222-55-7
N-(5-((2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methoxy)-2-methylpentan-2-yl)-3-methoxybenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: boron trichloride / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

2: iodine / 1,2-dichloro-ethane / 1.5 h / 20 - 93 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / methanol / 4 h / 20 °C / Inert atmosphere

4: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; iodine; boron trichloride; triethylamine; In methanol; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm201628y