N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Base Information

Chemical Name:N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide
CAS No.:1337930-77-4
Molecular Formula:C₃₀H₃₂Cl₂N₆O₄
Molecular Weight:611.528
Hs Code.:

Synonyms:N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

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Chemical Property of N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

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Technology Process of N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

There total 5 articles about N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1337932-08-7
N-(4-((2,3-dichloro-4-aminophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

: 530-62-1
1,1'-carbonyldiimidazole

: 285984-25-0,1244948-94-4
3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine

: 1337930-77-4
N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: 1,1'-carbonyldiimidazole; 3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine; In dichloromethane; at 20 ℃; for 4h;

N-(4-((2,3-dichloro-4-aminophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide; In tetrahydrofuran; dichloromethane; at 20 ℃; for 17h;

With sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 105250-17-7
2-amino-4-hydroxymethylpyridine

: 1337930-77-4
N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h

3.1: acetic acid; iron / 0.75 h / 60 °C

4.1: dichloromethane / 4 h / 20 °C

4.2: 17 h / 20 °C

With iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; mineral oil;

Reference yield:

: 36556-51-1
2,3-dichloro-1-fluoro-4-nitrobenzene

: 1337930-77-4
N-(4-((4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)-2,3-dichlorophenoxy)methyl)pyridin-2-yl)-2-methoxyacetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.2: 1 h

3.1: acetic acid; iron / 0.75 h / 60 °C

4.1: dichloromethane / 4 h / 20 °C

4.2: 17 h / 20 °C

With iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; mineral oil;