(R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

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Chemical Name:(R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone
CAS No.:131513-30-9
Molecular Formula:C₂₄H₂₆N₂O₄
Molecular Weight:406.481
Hs Code.:

Synonyms:(R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

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Chemical Property of (R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

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Technology Process of (R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

There total 6 articles about (R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131513-32-1
1-Morpholin-4-yl-3-(2-nitro-phenoxy)-propan-2-ol

: 131513-30-9
(R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) DMSO, trifluoroacetic anhydride, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 30 min, 2.) RT, 30 min

2: 96 percent / H₂ / Ra-Ni / ethyl acetate / 6 h / 2327.2 Torr

4: NaNO₂, 2 N aq. HCl / H₂O / 1 h / 0 °C

5: LiAlH₄ / tetrahydrofuran / 1 h / Heating

6: 1.) pyridinium 3-nitrobenzenesulfonic acid, 2.) AcOH / 1.) H₂O, reflux, 3 h, 2.) reflux, 1 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; acetic acid; dimethyl sulfoxide; pyridinium paratoluene sulfonic acid; triethylamine; trifluoroacetic anhydride; sodium nitrite; Ra-Ni; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/jm00079a016

Reference yield:

: 131513-33-2
3-(4-morpholinyl)-1-(2-nitrophenoxy)-2-propanone

: 131513-30-9
(R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂ / Ra-Ni / ethyl acetate / 6 h / 2327.2 Torr

3: NaNO₂, 2 N aq. HCl / H₂O / 1 h / 0 °C

4: LiAlH₄ / tetrahydrofuran / 1 h / Heating

5: 1.) pyridinium 3-nitrobenzenesulfonic acid, 2.) AcOH / 1.) H₂O, reflux, 3 h, 2.) reflux, 1 h

With hydrogenchloride; lithium aluminium tetrahydride; hydrogen; acetic acid; pyridinium paratoluene sulfonic acid; sodium nitrite; Ra-Ni; In tetrahydrofuran; water; ethyl acetate;
DOI:10.1021/jm00079a016

Reference yield:

: 131513-38-7
(R)-(+)-3,4-dihydro-3-<(4-morpholinyl)methyl>-2H-1,4-benzoxazine

: 131513-30-9
(R)-(+)-<2,3-dihydro-5-methyl-3-<(4-morpholinyl)methyl>pyrrolo<1,2,3-de>-1,4-benzoxazin-6-yl>(4-methoxyphenyl)methanone

Guidance literature:: Multi-step reaction with 3 steps

1: NaNO₂, 2 N aq. HCl / H₂O / 1 h / 0 °C

2: LiAlH₄ / tetrahydrofuran / 1 h / Heating

3: 1.) pyridinium 3-nitrobenzenesulfonic acid, 2.) AcOH / 1.) H₂O, reflux, 3 h, 2.) reflux, 1 h

With hydrogenchloride; lithium aluminium tetrahydride; acetic acid; pyridinium paratoluene sulfonic acid; sodium nitrite; In tetrahydrofuran; water;
DOI:10.1021/jm00079a016