Technology Process of oxazol-2-yl(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methanone
There total 12 articles about oxazol-2-yl(6-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)methanone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Dess-Martin periodane;
In
dichloromethane;
at 20 ℃;
for 2h;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: pyridine / 0 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
5.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
5.2: 0.67 h / -78 °C
5.3: 2 h / -78 °C
6.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); borane-THF; sodium carbonate; Dess-Martin periodane;
In
tetrahydrofuran; dichloromethane; water;
2.1: Suzuki coupling;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: palladium 10% on activated carbon; perchloric acid; hydrogen; acetic acid / 16 h
2.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux
3.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
4.1: pyridine / 0 - 20 °C / Inert atmosphere
5.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / tetrahydrofuran; water / 16 h / Reflux; Inert atmosphere
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
7.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
8.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
8.2: 0.67 h / -78 °C
8.3: 2 h / -78 °C
9.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
With
pyridine; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); perchloric acid; borane-THF; sulfuric acid; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; sodium carbonate; Dess-Martin periodane; acetic acid;
In
tetrahydrofuran; dichloromethane; water;
5.1: Suzuki coupling;
DOI:10.1021/jm101597x
