2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

Base Information

• Chemical Name: 2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide
• CAS No.: 1415694-47-1
• Molecular Formula: C₂₁H₁₇N₃O₂S₂
• Molecular Weight: 407.517
• Mol file: 1415694-47-1.mol

Synonyms:2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

Chemical Property of 2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

There total 2 articles about 2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-mercapto-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide (1415694-39-1) + benzyl chloride (100-44-7) → 2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide (1415694-47-1)

Guidance literature:

With sodium hydroxide; In water; at 20 ℃; for 5h;

DOI:10.1007/s00044-012-0324-3

Reference yield:

ethyl 2-amino-5-carbamoyl-4-methylthiophene-3-carboxylate (43028-63-3) → 2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide (1415694-47-1)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 15 h / Reflux

2: sodium hydroxide / water / 5 h / 20 °C

With potassium carbonate; sodium hydroxide; In water; acetonitrile;

DOI:10.1007/s00044-012-0324-3

Reference yield: 60.0%

2-(benzylthio)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide (1415694-47-1) → 2-(benzylsulfonyl)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide (1415694-50-6)

Guidance literature:

With potassium permanganate; acetic acid; In water; at 20 ℃;

DOI:10.1007/s00044-012-0324-3

upstream raw materials:

2-mercapto-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide

benzyl chloride

ethyl 2-amino-5-carbamoyl-4-methylthiophene-3-carboxylate

Downstream raw materials:

2-(benzylsulfonyl)-5-methyl-4-oxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide