3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

Base Information

Chemical Name:3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon
CAS No.:272130-91-3
Molecular Formula:C₂₃H₂₃FN₄O₃
Molecular Weight:422.459
Hs Code.:

Synonyms:3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

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Chemical Property of 3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

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Technology Process of 3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

There total 8 articles about 3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1765-93-1
4-fluoroboronic acid

: 165801-64-9
3-bromo-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

: 272130-91-3
3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; diethylene glycol dimethyl ether; at 95 ℃; for 1.5h;
DOI:10.1021/jm990448e

Reference yield:

: 72079-77-7
6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one

: 272130-91-3
3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

Guidance literature:: Multi-step reaction with 3 steps

1: NaH; NaI / dimethylformamide

2: NaBH₄ / methanol; CH₂Cl₂

3: 50 percent / Pd(PPh₃)4; Na₂CO₃ / ethanol; bis-(2-methoxy-ethyl) ether / 1.5 h / 95 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; sodium iodide; In methanol; ethanol; dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction / 3: Arylation;
DOI:10.1021/jm990448e

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 272130-91-3
3-(3-p-fluorophenyl-5-carbethoxyphenethyl)coformycin aglycon

Guidance literature:: Multi-step reaction with 7 steps

1: Pd(PPh₃)4 / dimethylformamide / 36 h / 80 °C

2: NaIO₄; RuO₂ / CCl₄; acetonitrile; H₂O / 0.25 h

3: NaBH₄ / methanol / 1 h / 20 °C

4: Ph₃P; CBr₄ / CH₂Cl₂ / 0.5 h / 0 °C

5: NaH; NaI / dimethylformamide

6: NaBH₄ / methanol; CH₂Cl₂

7: 50 percent / Pd(PPh₃)4; Na₂CO₃ / ethanol; bis-(2-methoxy-ethyl) ether / 1.5 h / 95 °C

With ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; sodium iodide; In methanol; tetrachloromethane; ethanol; dichloromethane; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; acetonitrile; 1: Substitution / 2: Oxidation / 3: Reduction / 4: Bromination / 5: Alkylation / 6: Reduction / 7: Arylation;
DOI:10.1021/jm990448e