tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

Base Information

Chemical Name:tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate
CAS No.:1349744-49-5
Molecular Formula:C₂₇H₂₈ClFN₆O₄
Molecular Weight:555.009
Hs Code.:

Synonyms:tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

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Chemical Property of tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

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Technology Process of tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

There total 10 articles about tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 660851-49-0
(5-cyano-pyrazin-2-yl)-carbamic acid phenyl ester

: 1349744-48-4
tert-butyl (4-amino-2-chloro-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

: 1349744-49-5
tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

Guidance literature:: In N,N-dimethyl-formamide; at 100 ℃; for 2h;

Reference yield:

: 113305-94-5
2-amino-5-cyanopyrazine

: 1349744-49-5
tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / dichloromethane; tetrahydrofuran / 0.25 h

1.2: 2 h / 50 °C

2.1: N,N-dimethyl-formamide / 2 h / 100 °C

With pyridine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1481-68-1
5-chloro-2,4-difluoronitrobenzene

: 1349744-49-5
tert-butyl (2-chloro-4-(3-(5-cyanopyrazin-2-yl)ureido)-5-methoxyphenyl)ethyl(3-fluorobenzyl)carbamate

Guidance literature:: Multi-step reaction with 9 steps

1.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.25 h / 0 °C

1.2: 0 - 20 °C

2.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 2 h / 80 °C

3.1: water; sodium chloride / dimethyl sulfoxide / 2 h / 120 °C

4.1: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4.2: 0.25 h

5.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 2 h / 20 °C

6.1: dimethyl sulfoxide / 5 h / 20 °C

7.1: triethylamine / dichloromethane / 1 h / 20 °C

8.1: zinc; ammonium chloride / methanol / 1 h / 45 °C

9.1: N,N-dimethyl-formamide / 2 h / 100 °C

With lithium borohydride; carbon tetrabromide; potassium tert-butylate; water; ammonium chloride; triethylamine; triphenylphosphine; sodium chloride; sodium hydroxide; zinc; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;