(RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

Base Information

Chemical Name:(RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid
CAS No.:170279-59-1
Molecular Formula:C₂₄H₂₃NO₄
Molecular Weight:389.451
Hs Code.:

Synonyms:(RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

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Chemical Property of (RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

Chemical Property:

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Technology Process of (RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

There total 7 articles about (RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873-62-1
m-cyanophenol

: 170279-59-1
(RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 68 percent / NaH / dimethylformamide / 4 h / 90 °C

2: 1.) Mg, I₂, 2.) aq. HCl / 1.) ether, reflux, 2.) rt

3: tert-BuOK / tetrahydrofuran / Ambient temperature

4: 71 percent / H₂, conc. HCl / Pd-C / methyl acetate; methanol / 6 h

5: NaH / dimethylformamide

6: aq. NaOH / dioxane

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; iodine; sodium hydride; magnesium; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; acetic acid methyl ester; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(97)84014-7

Reference yield:

: 61147-43-1
4-cyano-2-benzyloxypyridine

: 170279-59-1
(RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) Mg, I₂, 2.) aq. HCl / 1.) ether, reflux, 2.) rt

2: tert-BuOK / tetrahydrofuran / Ambient temperature

3: 71 percent / H₂, conc. HCl / Pd-C / methyl acetate; methanol / 6 h

4: NaH / dimethylformamide

5: aq. NaOH / dioxane

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; iodine; sodium hydride; magnesium; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; acetic acid methyl ester; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(97)84014-7

Reference yield:

: 1027833-39-1
1-(3-benzyloxyphenyl)-2-(2-methylphenyl)ethan-1-one

: 170279-59-1
(RS)-4-(2-methylphenyl)-5-oxo-5-[3-(pyridin-4-ylmethoxy)phenyl]pentanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tert-BuOK / tetrahydrofuran / Ambient temperature

2: 71 percent / H₂, conc. HCl / Pd-C / methyl acetate; methanol / 6 h

3: NaH / dimethylformamide

4: aq. NaOH / dioxane

With hydrogenchloride; sodium hydroxide; potassium tert-butylate; hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; acetic acid methyl ester; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(97)84014-7