4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

Base Information

Chemical Name:4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester
CAS No.:181259-08-5
Molecular Formula:C₂₉H₂₇NO₃
Molecular Weight:437.538
Hs Code.:

Synonyms:4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

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Chemical Property of 4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

There total 10 articles about 4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 144003-45-2
methyl 4-acetoxy-8-(phenylmethoxy)-2-naphthalenecarboxylate

: 181259-08-5
4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 100 percent / H₂ / 10percent Pd/C / ethanol / 2.5 h / 1810.02 Torr

2: pyridine / 18 h / Ambient temperature

3: 86 percent / <(Ph₃P)3P>4Pd, K₃PO₄ / dioxane / 18 h / 85 °C

4: methanol. NaOMe / 1 h / Ambient temperature

5: pyridine / CH₂Cl₂ / 1 h / 0 °C

6: 1.) LiCl, PdCl₂6H₅)3>2 / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h

7: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

8: CrO₃, H₂SO₄ / acetone / 38 h / 0 °C

9: CH₂Cl₂ / 1 h / Ambient temperature

10: 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; chromium(VI) oxide; dmap; bis-triphenylphosphine-palladium(II) chloride; potassium phosphate; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen; dihydrogen peroxide; sodium methylate; lithium chloride; palladium on activated charcoal; In 1,4-dioxane; ethanol; dichloromethane; acetone;
DOI:10.1021/jm950699x

Reference yield:

: 181259-02-9
8-Phenyl-4-vinyl-naphthalene-2-carboxylic acid methyl ester

: 181259-08-5
4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

2: CrO₃, H₂SO₄ / acetone / 38 h / 0 °C

3: CH₂Cl₂ / 1 h / Ambient temperature

4: 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With chromium(VI) oxide; dmap; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; In dichloromethane; acetone;
DOI:10.1021/jm950699x

Reference yield:

: 181258-99-1
4-Hydroxy-8-phenyl-naphthalene-2-carboxylic acid methyl ester

: 181259-08-5
4-[(Methyl-phenethyl-carbamoyl)-methyl]-8-phenyl-naphthalene-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / CH₂Cl₂ / 1 h / 0 °C

2: 1.) LiCl, PdCl₂6H₅)3>2 / 1.) DMF, RT, 15 min, 2.) DMF, RT, 12 h

3: 1.) 9-BBN, 2.) aq. H₂O₂ / 1.) THF, RT, 48 h, 2.) THF, from 0 deg C to RT, 2 h

4: CrO₃, H₂SO₄ / acetone / 38 h / 0 °C

5: CH₂Cl₂ / 1 h / Ambient temperature

6: 4-(dimethylamino)pyridine / CH₂Cl₂ / 18 h / Ambient temperature

With pyridine; chromium(VI) oxide; dmap; bis-triphenylphosphine-palladium(II) chloride; 9-borabicyclo[3.3.1]nonane dimer; sulfuric acid; dihydrogen peroxide; lithium chloride; In dichloromethane; acetone;
DOI:10.1021/jm950699x