1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

Base Information

Chemical Name:1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide
CAS No.:1269792-93-9
Molecular Formula:C₁₉H₁₈ClN₅OS
Molecular Weight:399.904
Hs Code.:

Synonyms:1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

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Chemical Property of 1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

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Technology Process of 1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

There total 4 articles about 1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1269792-88-2
1-(2-p-chlorobenzylidinehydrazinyl)-4-cyano-5,6,7,8-tetrahydroisoquinoline-3-sulfanylacetamide

: 1269792-93-9
1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

Guidance literature:: With sodium ethanolate; In ethanol; for 0.333333h; Reflux;
DOI:10.1016/j.ejmech.2010.11.036

Reference yield:

: 50706-78-0
2,3,5,6,7,8-hexahydro-1-morpholin-4-yl-3-thioxo-isoquinoline-4-carbonitrile

: 1269792-93-9
1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrazine hydrate / ethanol / 2 h / Reflux

2: piperidine / ethanol / 2.08 h / Reflux

3: sodium acetate / ethanol / 2 h / Reflux

4: sodium ethanolate / ethanol / 0.33 h / Reflux

With piperidine; sodium ethanolate; sodium acetate; hydrazine hydrate; In ethanol; 4: Thorpe-Ziegler cyclization;
DOI:10.1016/j.ejmech.2010.11.036

Reference yield:

: 1269792-60-0
1-hydrazino-3-thioxo-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile

: 1269792-93-9
1-amino-5-(2-p-chlorobenzylidenehydrazinyl)-6,7,8,9-tetrahydrothieno[2,3-c]isoquinoline-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / ethanol / 2.08 h / Reflux

2: sodium acetate / ethanol / 2 h / Reflux

3: sodium ethanolate / ethanol / 0.33 h / Reflux

With piperidine; sodium ethanolate; sodium acetate; In ethanol; 3: Thorpe-Ziegler cyclization;
DOI:10.1016/j.ejmech.2010.11.036