(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Base Information

Chemical Name:(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate
CAS No.:1403324-67-3
Molecular Formula:C₄₂H₆₆N₆O₉
Molecular Weight:799.021
Hs Code.:

(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Synonyms:(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Suppliers and Price of (S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

There total 7 articles about (S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403324-69-5
C₂₃H₄₂N₂O₆

: 1403324-67-3
(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine; methanesulfonyl chloride / dichloromethane / 18 h / 20 °C / Inert atmosphere

2: dichloromethane / 2.5 h / 0 °C / Inert atmosphere

3: potassium carbonate / acetone / 24 h / 20 °C / Inert atmosphere

4: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

5: diethylamine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

6: 2 h / 20 °C

With potassium carbonate; methanesulfonyl chloride; diethylamine; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo301723y

Reference yield:

: 1403324-65-1
(S)-tert-butyl 2-((2S,3R,E)-2-((tert-butoxycarbonyl)amino)-4-(chloromethyl)-3-methylhex-4-enamido)-4-methylpentanoate

: 1403324-67-3
(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: dichloromethane / 2.5 h / 0 °C / Inert atmosphere

2: potassium carbonate / acetone / 24 h / 20 °C / Inert atmosphere

3: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

4: diethylamine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

5: 2 h / 20 °C

With potassium carbonate; diethylamine; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo301723y

Reference yield:

: C₂HF₃O₂*C₁₈H₃₃ClN₂O₃

: 1403324-67-3
(S)-tert-butyl 2-((2S,3R,4E)-1-((S)-2-benzamido-6-(2,3-bis-(tert-butoxycarbonyl)guanidino)hexanoyl)-4-ethylidene-3-methylpyrrolidine-2-carboxamido)-4-methylpentanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 24 h / 20 °C / Inert atmosphere

2: triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one / tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

3: diethylamine / tetrahydrofuran / 5 h / 20 °C / Inert atmosphere

4: 2 h / 20 °C

With potassium carbonate; diethylamine; triethylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; acetone;
DOI:10.1021/jo301723y