Technology Process of indolo<1,2-b><2,7>naphthyridine-5,12-quinone
There total 1 articles about indolo<1,2-b><2,7>naphthyridine-5,12-quinone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) LDA / tetrahydrofuran; hexane / 1.) THF, hexane, -75 deg C to 10 deg C, 3 h, 2. THF, a) -100 deg C, 2.5 h, b) up to -50 deg C, 3 h, c) up to r.t., 12 h
2: K2CO3 / methanol; H2O / 4.5 h / Heating
3: Ac2O / 1.) 85 deg C, 15 h, 2.) 85-90 deg C, 6 h
With
acetic anhydride; potassium carbonate; lithium diisopropyl amide;
In
tetrahydrofuran; methanol; hexane; water;
DOI:10.1021/jo00048a022
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) THF, diethylether, a) -78 deg C, 1h, b) to -10 deg C, 2) room temp., 30 min
3: 85 percent / bis(trifluoroacetoxy)-iodobenzene / acetonitrile; H2O / Ambient temperature
4: 89 percent / trifluoroacetic acid, sodium borohydride / ethanol / Ambient temperature
With
sodium tetrahydroborate; trifluoroacetic acid; bis-[(trifluoroacetoxy)iodo]benzene;
In
ethanol; water; acetonitrile;
DOI:10.1016/S0040-4020(01)82308-5
