5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

Base Information

Chemical Name:5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile
CAS No.:165558-96-3
Molecular Formula:C₃₅H₃₄N₄O₃Si
Molecular Weight:586.765
Hs Code.:

5-<methyl<<2-<(tert-butyldiphenylsiloxy)methyl>pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

Synonyms:5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

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Chemical Property of 5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

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Technology Process of 5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

There total 7 articles about 5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 165558-63-4
5-chloro-8-nitronaphthalene-1-carbonitrile

: 165558-95-2
N-methyl<<2-<(tert-butyldiphenylsiloxy)methyl>pyridin-4-yl>methyl>amine

: 165558-96-3
5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 85 ℃; for 6h;
DOI:10.1021/jm00011a009

Reference yield:

: 165558-61-2
N-(5-bromo-4-nitro-[1]naphthyl)-acetamide

: 165558-96-3
5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / dimethylformamide / 1 h / Heating

2: 89 percent / 2N NaOH / methanol / 0.5 h / Heating

3: 86 percent / CuCl₂, t-BuNO₂ / acetonitrile / 0.5 h / Ambient temperature

4: 47 percent / DIEA / dimethylsulfoxide / 6 h / 85 °C

With sodium hydroxide; 2-Methyl-2-nitropropane; N-ethyl-N,N-diisopropylamine; copper dichloride; In methanol; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00011a009

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 165558-96-3
5-pyridin-4-yl>methyl>amino>-8-nitronaphthalene-1-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / DMAP, Et₃N / CH₂Cl₂ / 16 h / Ambient temperature

2: 86 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

3: 47 percent / DIEA / dimethylsulfoxide / 6 h / 85 °C

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00011a009