(1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

Base Information

Chemical Name:(1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate
CAS No.:1432791-85-9
Molecular Formula:C₂₃H₂₅NO₅
Molecular Weight:395.455
Hs Code.:

Synonyms:(1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

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Chemical Property of (1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

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Technology Process of (1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

There total 2 articles about (1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₃₉NO₅Si

: 1432791-85-9
(1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

: 1432791-86-0
(1R,3aR,8bS)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 0.166667h; Overall yield = 88 %; Overall yield = 27.1 mg; Inert atmosphere;
DOI:10.1021/ol4010646

Reference yield:

: 75073-97-1
dimethyl 2-(4-methoxyphenyl)cyclopropane-1,1-dicarboxylate

: 108939-97-5
1-(tert-Butyldimethylsilyl)-3-methylindole

: 1432791-85-9
(1R,3aS,8bR)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

: 1432791-86-0
(1R,3aR,8bS)-dimethyl 1-(4-methoxyphenyl)-8b-methyl-1,3a,4,8b-tetrahydrocyclopenta[b]indole-3,3(2H)-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 20 °C / Inert atmosphere; Molecular sieve; Glovebox

2: hydrogenchloride / methanol / 0.17 h / 20 °C / Inert atmosphere

With hydrogenchloride; scandium tris(trifluoromethanesulfonate); In methanol; 1,2-dichloro-ethane;
DOI:10.1021/ol4010646