1-{O⁴-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[5'-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2′-deoxyguanosinyl]}butane

Base Information

• Chemical Name: 1-{O⁴-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[5'-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2′-deoxyguanosinyl]}butane
• CAS No.: 1421765-85-6
• Molecular Formula: C₇₄H₇₅N₇O₁₅
• Molecular Weight: 1302.45

Synonyms:1-{O⁴-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[5'-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2′-deoxyguanosinyl]}butane

Chemical Property of 1-{O⁴-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[5'-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2′-deoxyguanosinyl]}butane

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Technology Process of 1-{O⁴-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[5'-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2′-deoxyguanosinyl]}butane

There total 1 articles about 1-{O⁴-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[5'-O-(4,4′-dimethoxytrityl)-N²-phenoxyacetyl-2′-deoxyguanosinyl]}butane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

1-{O4-[3′-O-(t-butyldimethylsilyl)-5'-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O6-[3'-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosinyl]}butane (1421765-83-4) → 1-{O4-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O6-[5'-O-(4,4′-dimethoxytrityl)-N2-phenoxyacetyl-2′-deoxyguanosinyl]}butane (1421765-85-6)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;

DOI:10.1021/bc300553u

Reference yield: 85.0%

1-{O4-[5′-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O6-[5'-O-(4,4′-dimethoxytrityl)-N2-phenoxyacetyl-2′-deoxyguanosinyl]}butane (1421765-85-6) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 1-{O4-[3'-O-(β-cyanoethyl-N,N′-diisopropyl)-5'-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O6-[3'-O-(β-cyanoethyl-N,N'-diisopropyl)-5′-O-(4,4'-dimethoxytrityl)-N2-phenoxyacetyl-2'-deoxyguanosinyl]}butane (1421765-87-8,1421765-88-9,1421765-89-0,1421765-90-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 1.5h;

DOI:10.1021/bc300553u

upstream raw materials:

1-{O⁴-[3′-O-(t-butyldimethylsilyl)-5'-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[3'-O-(t-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-N²-phenoxyacetyl-2'-deoxyguanosinyl]}butane

Downstream raw materials:

1-{O⁴-[3'-O-(β-cyanoethyl-N,N′-diisopropyl)-5'-O-(4,4′-dimethoxytrityl)thymidinyl]}-4-{O⁶-[3'-O-(β-cyanoethyl-N,N'-diisopropyl)-5′-O-(4,4'-dimethoxytrityl)-N²-phenoxyacetyl-2'-deoxyguanosinyl]}butane

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