(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

Base Information

Chemical Name:(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid
CAS No.:1361001-05-9
Molecular Formula:C₂₁H₁₉FO₂S
Molecular Weight:354.445
Hs Code.:

Synonyms:(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

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Chemical Property of (E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

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Technology Process of (E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

There total 4 articles about (E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1361001-06-0
(E)-ethyl 2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoate

: 1361001-05-9
(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 5h;
DOI:10.1021/jm201528b

Reference yield:

: 1361000-79-4
ethyl 2-(5-fluoro-1H-inden-3-yl)-2-methylpropanoate

: 1361001-05-9
(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 20 - 70 °C

2: lithium hydroxide / tetrahydrofuran; water / 5 h / 20 °C

With sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1021/jm201528b

Reference yield:

: 1481-32-9
6-fluoroindan-1-one

: 1361001-05-9
(E)-2-(5-fluoro-1-(4-(methylthio)benzylidene)-1H-inden-3-yl)-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.33 h / -75 °C / Inert atmosphere

1.2: 2 h / -75 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid; calcium chloride / toluene / 16 h / Reflux

3.1: sodium hydroxide / methanol / 20 - 70 °C

4.1: lithium hydroxide / tetrahydrofuran; water / 5 h / 20 °C

With toluene-4-sulfonic acid; calcium chloride; sodium hydroxide; lithium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; water; toluene;
DOI:10.1021/jm201528b