5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Base Information

Chemical Name:5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide
CAS No.:101544-45-0
Molecular Formula:C₂₅H₂₅N₃O₂
Molecular Weight:399.492
Hs Code.:

5-<1-hydroxy-2-<bis(phenylmethyl)amino>ethyl>-1H-indole-7-carboxamide

Synonyms:5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Suppliers and Price of 5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of 5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

There total 10 articles about 5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 101544-44-9
2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

: 101544-45-0
5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Guidance literature:: With manganese(IV) oxide; In tetrahydrofuran; for 9h; Ambient temperature;
DOI:10.1021/jm00156a019

Reference yield:

: 101544-43-8
2,3-dihydro-5-<1-hydroxy-2-ethyl>-1H-indole-7-carbonitrile

: 101544-45-0
5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 35percent hydrogen peroxide / dimethylsulfoxide / 0.25 h / 15 °C

2: 91 percent / manganese(IV) oxide / tetrahydrofuran / 9 h / Ambient temperature

With manganese(IV) oxide; dihydrogen peroxide; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1021/jm00156a019

Reference yield:

: 16078-30-1
1-Acetyl-2,3-dihydro-1H-indole

: 101544-45-0
5-<1-hydroxy-2-ethyl>-1H-indole-7-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1: 1.) aluminum chloride / 1.) 1,2-dichloroethane, 20 min, 2.) 1,2-dichloroethane, 50 deg C, 1 h

2: dimethylformamide / 2 h / 60 °C

3: NaBH₄ / ethanol / 1.) RT, 4.5 h, 2.) 50 deg C, 1 h

4: 94.5 percent / pyridine / Ambient temperature

5: 85.9 percent / 90percent nitric acid / acetic acid / 6 h / Ambient temperature

6: 93 percent / acetic acid, zinc dust / ethanol / 0.5 h / Ambient temperature

7: 1.) a) hydrochloric acid, sodium nitrite, b) aq. HBF₄, 2.) potassium cyanide / 1.) -5 deg C, 20 min, 2.) DMSO, 20 deg C, 1.5 h

8: 5N aq. sodium hydroxide / ethanol / 1.5 h / 20 °C

9: 35percent hydrogen peroxide / dimethylsulfoxide / 0.25 h / 15 °C

10: 91 percent / manganese(IV) oxide / tetrahydrofuran / 9 h / Ambient temperature

With pyridine; hydrogenchloride; potassium cyanide; manganese(IV) oxide; sodium hydroxide; sodium tetrahydroborate; tetrafluoroboric acid; aluminium trichloride; dihydrogen peroxide; nitric acid; acetic acid; zinc; sodium nitrite; In tetrahydrofuran; ethanol; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1021/jm00156a019