N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea

Base Information

• Chemical Name: N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea
• CAS No.: 1352504-84-7
• Molecular Formula: C₂₄H₃₂ClF₃N₄O₄SSi
• Molecular Weight: 593.142

Synonyms:N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea

Chemical Property of N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea

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Technology Process of N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea

There total 1 articles about N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene (23163-86-2) + 5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine (130128-70-0) → N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea (1352504-84-7)

Guidance literature:

In N,N-dimethyl-formamide; at 0 ℃; for 1h;

DOI:10.1016/j.bmc.2011.10.021

Reference yield: 83.0%

N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea (1352504-84-7) → 5-(5'-amino-5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)tetrazole (1352504-87-0)

Guidance literature:

With sodium azide; triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.10.021

Reference yield: 60.0%

N-(5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea (1352504-84-7) → N-(5'-deoxy-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea (1352504-86-9)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2011.10.021

upstream raw materials:

1-chloro-4-isothiocyanato-2-(trifluoromethyl)benzene

5'-amino-3'-O-(tert-butyldimethylsilyl)-5’-deoxythymidine

Downstream raw materials:

N-(5'-deoxy-β-D-thymidin-5'-yl)-N'-(4-chloro-3-trifluoromethylphenyl)thiourea

5-(5'-amino-5'-deoxy-3'-O-tert-butyldimethylsilyl-β-D-thymidin-5'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)tetrazole

5-(5'-amino-5'-deoxy-β-D-thymidin-5'N-yl)-1-(4-chloro-3-trifluoromethylphenyl)tetrazole

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