methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate

Base Information

• Chemical Name: methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate
• CAS No.: 1325217-54-6
• Molecular Formula: C₂₉H₄₈N₂O₅
• Molecular Weight: 504.711
• Mol file: 1325217-54-6.mol

Synonyms:methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate

Chemical Property of methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate

There total 2 articles about methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

2-(2-(di-octylamino)-2-oxoethoxy)acetic acid (135447-09-5) + 3-aminomethyl-benzoic acid methyl ester hydrochloride → methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate (1325217-54-6)

Guidance literature:

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.201100443

Reference yield:

2-dioctylcarbamoylmethoxy-N-[3-[(2-dioctyl-carbamoylmethoxy-acetylamino)methyl]benzyl]acetamide (1027755-54-9) → methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate (1325217-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: dodecane; octanol / Irradiation

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine / dichloromethane / 24 h / 20 °C / Inert atmosphere

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dodecane; octanol; dichloromethane;

DOI:10.1002/ejoc.201100443

Reference yield: 81.0%

methyl 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoate (1325217-54-6) → 3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoic acid (1325217-43-3)

Guidance literature:

With ethanol; potassium hydroxide; In tetrahydrofuran; at 70 ℃; for 3h;

DOI:10.1002/ejoc.201100443

upstream raw materials:

2-dioctylcarbamoylmethoxy-N-[3-[(2-dioctyl-carbamoylmethoxy-acetylamino)methyl]benzyl]acetamide

2-(2-(di-octylamino)-2-oxoethoxy)acetic acid

Downstream raw materials:

3-({2-[2-(dioctylamino)-2-oxoethoxy]acetamido}methyl)benzoic acid