2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

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Chemical Name:2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid
CAS No.:1428900-86-0
Molecular Formula:C₃₁H₃₅FN₂O₆
Molecular Weight:550.627
Hs Code.:

Synonyms:2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

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Chemical Property of 2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

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Technology Process of 2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

There total 9 articles about 2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: C₃₂H₃₇FN₂O₆

: 1428900-86-0
2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 40 ℃;
DOI:10.1016/j.bmcl.2016.01.031

Reference yield:

: 123342-40-5
methyl 2-(4-hydroxyphenyl)-2-methylpropanoate

: 1428900-86-0
2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: potassium phosphate / N,N-dimethyl acetamide / 70 °C

2: potassium phosphate / N,N-dimethyl acetamide / 100 °C

3: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C

4: potassium carbonate / ethyl acetate / 20 °C

5: N,N-dimethyl acetamide / 90 °C

6: sodium hydroxide; water / tetrahydrofuran; methanol / 40 °C

With potassium phosphate; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1016/j.bmcl.2016.01.031

Reference yield:

: 1428901-06-7
methyl 2-[4-(3-fluoro-5-nitrophenoxy)phenyl]-2-methylpropanoate

: 1428900-86-0
2-{4-[3-(4-fluorophenoxy)-5-{[(3-hydroxy-3-isobutyl-1-pyrrolidinyl)carbonyl]amino}phenoxy]phenyl}-2-methylpropanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate / N,N-dimethyl acetamide / 100 °C

2: hydrogen; 5%-palladium/activated carbon / methanol / 20 °C

3: potassium carbonate / ethyl acetate / 20 °C

4: N,N-dimethyl acetamide / 90 °C

5: sodium hydroxide; water / tetrahydrofuran; methanol / 40 °C

With potassium phosphate; 5%-palladium/activated carbon; water; hydrogen; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; ethyl acetate;
DOI:10.1016/j.bmcl.2016.01.031