2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

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Chemical Name:2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide
CAS No.:191109-58-7
Molecular Formula:C₃₀H₃₃Cl₃N₄O₆
Molecular Weight:651.974
Hs Code.:

Synonyms:2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

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Chemical Property of 2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

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Technology Process of 2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

There total 5 articles about 2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 22241-07-2
nitrilotriacetic acid trimethyl ester

: 191109-51-0
(S)-1-(4-chlorophenyl)-2-hydroxyethylamine

: 191109-58-7
2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: at 80 ℃; for 40h;
DOI:10.1016/S0040-4020(97)00322-0

Reference yield:

: 1073-67-2,24991-47-7
4-vinylbenzyl chloride

: 191109-58-7
2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: K₃Fe(CN)6, K₂CO₃, (DHQD)2-PHAL, K₂OsO₄(H₂O)2

2: NaOH

3: NaN₃, H₂O / dimethylformamide

4: LiAlH₄ / tetrahydrofuran / Ambient temperature

5: 85 percent / 40 h / 80 °C

With sodium hydroxide; potassium osmate(VI); lithium aluminium tetrahydride; sodium azide; water; potassium carbonate; 1,4-bis(9-O-dihydroquinidine)phthalazine; potassium hexacyanoferrate(III); In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00322-0

Reference yield:

: 152142-03-5
(1R)-1-(4-chlorophenyl)-1,2-ethanediol

: 191109-58-7
2-(Bis-{[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethylcarbamoyl]-methyl}-amino)-N-[(S)-1-(4-chloro-phenyl)-2-hydroxy-ethyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH

2: NaN₃, H₂O / dimethylformamide

3: LiAlH₄ / tetrahydrofuran / Ambient temperature

4: 85 percent / 40 h / 80 °C

With sodium hydroxide; lithium aluminium tetrahydride; sodium azide; water; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(97)00322-0