3-Pyridinemethanol,6-(1-methylethyl)-(9CI)

Base Information

• Chemical Name: 3-Pyridinemethanol,6-(1-methylethyl)-(9CI)
• CAS No.: 107756-02-5
• Molecular Formula: C9H13 N O
• Molecular Weight: 151.208
• Hs Code.: 2933399090
• Mol file: 107756-02-5.mol

Synonyms:3-Pyridinemethanol,6-(1-methylethyl)-(9CI)

Chemical Property of 3-Pyridinemethanol,6-(1-methylethyl)-(9CI)

Chemical Property:

• PSA: 33.12000
• LogP: 1.69730

Purity/Quality:

99%min ^*data from raw suppliers

(6-Isopropylpyridin-3-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinemethanol,6-(1-methylethyl)-(9CI)

There total 2 articles about 3-Pyridinemethanol,6-(1-methylethyl)-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Ethyl 6-isopropylnicotinate (118419-91-3) → 6-(1-methylethyl)-3-pyridinemethanol (107756-02-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1021/jm00123a012

Reference yield:

6-isopropylnicotinic acid (886214-81-9) → 6-(1-methylethyl)-3-pyridinemethanol (107756-02-5)

Guidance literature:

Multi-step reaction with 2 steps

1: conc. H₂SO₄ / Heating

2: 91 percent / LiAlH₄ / diethyl ether / Heating

With lithium aluminium tetrahydride; sulfuric acid; In diethyl ether;

DOI:10.1021/jm00123a012

Reference yield: 100.0%

6-(1-methylethyl)-3-pyridinemethanol (107756-02-5) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → C21H28BNO3

Guidance literature:

With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

upstream raw materials:

Ethyl 6-isopropylnicotinate

6-isopropylnicotinic acid

Downstream raw materials:

6-Isopropyl-3-pyridinecarbaldehyde

(E)-N-[4-(4-Benzhydryl-piperazin-1-yl)-butyl]-3-(6-isopropyl-pyridin-3-yl)-acrylamide

Refernces